A new ferulic acid ester from Rhodiola wallichiana var. cholaensis (Crassulaceae). Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Song, Yaling; Zhou, Jianming; Wang, Xuejing; Xie, Xue; Zhao, Yiwu; Ni, Fuyong; Huang, Wenzhe; Wang, Zhenzhong; Xiao, Wei
• Is Part Of: Natural product research. Volume 32:Issue 1(2018)
• Page Start: 77
• Page End: 84
• Publication Date: 2018-01-02
• Subjects: Rhodiola wallichiana var. cholaensis -- ferulic acid ester -- phenolics -- protective effects -- H9c2 cardiomyocytes; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1335724
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new ferulic acid ester, 6-feruloyloxyhexanoic acid (1 ), was isolated along with 10 known ones (2 –11), from the concentrated water extract of Rhodiola wallichiana var . cholaensis. Their chemical structures were elucidated on the basis of extensive spectroscopic methods including Two-dimensional nuclear magnetic resonance (2D NMR) experiments. Compound3 was isolated from this plant for the first time. The protective effects against H2 O2 -induced myocardial cell injury in cultured H9c2 cells were also evaluated. Compounds1, 5 and7 –11 provided significant protective effects on H2 O2 -induced H9c2 cells injury at the concentration of 25 μg/mL. And the protective effects of compound1 was also investigated by the oxygen–glucose deprivation/reperfusion (OGD/R) tests. Abstract :