A novel ferrocenyl–naphthalimide as a multichannel probe for the detection of Cu(ii) and Hg(ii) in aqueous media and living cells. Issue 2 (19th December 2017)

• Record Type: Journal Article
• Authors: Dong, Junyang; Hu, Jianfeng; Baigude, Huricha; Zhang, Hao
• Is Part Of: Dalton transactions. Volume 47:Issue 2(2017)
• Page Start: 314
• Page End: 322
• Publication Date: 2017-12-19
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c7dt03982d
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : The first reported probe that has been used for the bifunctional fluorescent monitoring Cu 2+ and Hg 2+ ions in living cells. Abstract : A novel ferrocenyl–naphthalimide multichannel probe1 was designed and synthesized using a facile method. The color of the solution containing probe1 changed from yellow to colorless upon the addition of Cu 2+ or Hg 2+ . Interestingly, probe1 exhibited highly selective fluorescent turn-on for Cu 2+ and turn-off for Hg 2+ in aqueous solution. Probe1 was an electrochemical Cu 2+ and Hg 2+ ion sensor, in which the Fc/Fc + redox couple was significantly shifted (Δ E 1/2 = 178 mV and Δ E 1/2 = 53 mV, respectively) upon complexation. Therefore, probe1 can act as a naked-eye chemosensor, as well as an electrochemical and a fluorescent probe for Cu 2+ and Hg 2+ . Furthermore, this is the first reported probe that can be used for the bifunctional fluorescent detection of intracellular Cu 2+ and Hg 2+ by fluorescent imaging studies. These characteristics give this probe considerable potential in the study and analysis of Cu 2+ and Hg 2+ in complex biosystems.