Physico-chemical studies of resveratrol, methyl-jasmonate and cyclodextrin interactions: an approach to resveratrol bioproduction optimization. Issue 3 (4th January 2018)

• Record Type: Journal Article
• Authors: Oliva, E.; Mathiron, D.; Bertaut, E.; Landy, D.; Cailleu, D.; Pilard, S.; Clément, C.; Courot, E.; Bonnet, V.; Djedaïni-Pilard, F.
• Is Part Of: RSC advances. Volume 8:Issue 3(2018)
• Page Start: 1528
• Page End: 1538
• Publication Date: 2018-01-04
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra11619e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The role of cyclodextrins in the bioproduction of resveratrol in the presence of methyl-jasmonate is rationalized, leading to solutions for the improvement of bioproduction. Abstract : trans -Resveratrol (RSV) is a natural phenolic molecule of the stilbene family known for its anti-oxidant properties in the field of nutraceuticals and cosmetics. Its production by grapevine cell suspensions is induced by the addition to the culture medium of elicitor compounds, methyl jasmonate (MeJA) and cyclodextrins (CDs). Physico-chemical studies were performed to understand the mechanism of action of CDs on this bioproduction of RSV. Inclusion complexes of RSV in CDs were first observed and then interactions with MeJA were identified using various analytical techniques such as UV and nuclear magnetic resonance (NMR) spectroscopies, mass spectrometry (MS) and isothermal titration calorimetry (ITC).