Evaluation of macrophage injury and activation by amphotericin B-loaded polymeric nanoparticles. Issue 5 (24th March 2018)

• Record Type: Journal Article
• Authors: Ashraf, MD.; Farooqi, Javed Abrar; Javed, Kalim
• Is Part Of: International journal of polymeric materials. Volume 67:Issue 5(2018)
• Page Start: 297
• Page End: 306
• Publication Date: 2018-03-24
• Subjects: Amphotericin B -- drug delivery -- macrophage -- NIPAM -- phagocytosis; NIPAM: N-isopropylacrylamide -- AA: acrylic acid -- VP: vinyl pyrrolidone -- AmB: amphotericin B -- MBA: N, N-methylene-bis-acrylamide -- ROS: reactive oxygen species -- SOD: superoxide dismutase -- DSC: differential scanning calorimeter -- TGA: thermogravimetric analysis -- DNA: deoxy ribonucleic acid -- IFN-γ, type II interferon -- TGF: transforming growth factor; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2017.1323216
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: The objectives of present work were to prepare water soluble nanoformulation of amphotericin B by radical polymerization using N -isopropylacrylamide–acrylic acid and vinyl pyrrolidone for targeted delivery and minimized toxicity in mild experimental conditions with relatively narrow size distribution. The prepared formulations were extensively characterized in terms of size, morphology, thermal stability, drug loading and toxicity. The results demonstrates that the prepared nanoformulation have the potential to deliver amphotericin B with increased bioavailability and cellular uptake. GRAPHICAL ABSTRACT: