Lost in clocks: non‐canonical circadian oscillation discovered in Drosophila cells. Issue 9 (24th September 2018)

• Record Type: Journal Article
• Authors: Ode, Koji L; Ueda, Hiroki R
• Is Part Of: Molecular systems biology. Volume 14:Issue 9(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-09-24
• Subjects: Molecular biology -- Periodicals; Systems biology -- Periodicals; 572.8
• DOI: 10.15252/msb.20188567
• Languages: English
• ISSNs: 1744-4292

Abstract

Abstract : In most organisms, cell‐autonomous circadian clocks are driven by a transcription–translation negative feedback loop (TTFL). Per was the first identified clock gene in the fruit fly and is a core component of the circadian TTFL. Surprisingly, in their recent study, Rey et al (2018 ) demonstrate the presence of apparent circadian rhythmicity in a fly cell line that does not express several core clock genes including per (Rey et al, 2018 ). Quantitative multi‐omics measurements allowed the identification of unknown oscillating components and revealed hundreds of transcripts, proteins, and metabolites showing 24‐h rhythmicity, suggesting that at least in the fly, the circadian clock may be driven by non‐canonical (i.e., independent of per ‐driven TTFL) molecular mechanisms. Abstract : Cell‐autonomous circadian clocks are mostly driven by a transcription‐translation negative feedback loop. In their recent study, Rey et al, 2018 ) identify transcripts, proteins and metabolites showing 24‐h rhythmicity in Drosophila cells that do not express core clock genes.