Metal‐ and Base‐Free Direct N‐Arylation of Pyridazinones by Using Diaryliodonium Salts: An Anion Effect. Issue 8 (1st July 2018)

• Record Type: Journal Article
• Authors: Xu, Bowen; Han, Jianwei; Wang, Limin
• Is Part Of: Asian journal of organic chemistry. Volume 7:Issue 8(2018)
• Page Start: 1674
• Page End: 1680
• Publication Date: 2018-07-01
• Subjects: anions -- arylation -- diaryliodonium salts -- radical reactions; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201800268
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: An efficient N‐arylation of pyridazinones with diaryliodonium salts has been developed without using base or metal catalysts. The reaction tolerated a variety of both diaryliodonium salts and pyridazinone derivatives with diverse functional groups. Furthermore, a drug candidate for treatment of neuropathic pain was synthesized with this procedure in good yield. Abstract : Can you please pass the salt? An efficient N‐arylation of pyridazinones with diaryliodonium salts has been developed. The reaction did not require base or metal catalysts and tolerated a variety of diaryliodonium salts and pyridazinone derivatives with diverse functional groups.