Advantages of patient‐derived orthotopic mouse models and genetic reporters for developing fluorescence‐guided surgery. Issue 2 (6th August 2018)

• Record Type: Journal Article
• Authors: Lwin, Thinzar M; Hoffman, Robert M; Bouvet, Michael
• Other Names: Karakousis Giorgos guestEditor.; Bouvet Michael guestEditor.
• Is Part Of: Journal of surgical oncology. Volume 118:Issue 2(2018)
• Page Start: 253
• Page End: 264
• Publication Date: 2018-08-06
• Subjects: fluorescence‐guided surgery (FGS) -- genetic reporters -- patient‐derived orthotopic xenografts (PDOX) -- preclinical mouse models -- surgical orthotopic implantation (SOI); Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.25150
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract : Fluorescence‐guided surgery can enhance the surgeon's ability to achieve a complete oncologic resection. There are a number of tumor‐specific probes being developed with many preclinical mouse models to evaluate their efficacy. The current review discusses the different preclinical mouse models in the setting of probe evaluation and highlights the advantages of patient‐derived orthotopic xenografts (PDOX) mouse models and genetic reporters to develop fluorescence‐guided surgery.