The effectiveness of exercise‐based rehabilitation to patients with myeloproliferative neoplasms—An explorative study. (11th June 2018)

• Record Type: Journal Article
• Authors: Pedersen, Kasper Mønsted; Zangger, Graziella; Brochmann, Nana; Grønfeldt, Birk Mygind; Zwisler, Ann‐Dorthe; Hasselbalch, Hans Carl; Tang, Lars Hermann
• Is Part Of: European journal of cancer care. Volume 27:Number 5(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-06-11
• Subjects: exercise -- fatigue -- myeloproliferative neoplasms -- non‐pharmacological interventions -- quality of life -- rehabilitation; Cancer -- Nursing -- Periodicals; 616.994
• DOI: 10.1111/ecc.12865
• Languages: English
• ISSNs: 0961-5423

Abstract

Abstract: The aim of the study was to determine the impact of an interdisciplinary exercise‐based rehabilitation intervention on fatigue and quality of life (QOL) in patients with Philadelphia‐negative myeloproliferative neoplasms (MPNs). At the Danish Knowledge Centre for Rehabilitation and Palliative Care, a 5‐day interdisciplinary exercise‐based rehabilitation intervention was carried out on 48 patients with MPN. It was followed by 12 weeks of self‐exercising prior to follow‐up. Initially and at follow‐up, participants filled out validated questionnaires; Brief Fatigue Inventory, Multidimensional Fatigue Inventory, European Organization for Research and Treatment of Cancer Quality‐of‐Life questionnaire, Myeloproliferative Neoplasm Symptom Assessment Form and Hospital Anxiety and Depression Scale. Maximal oxygen uptake and muscular strength were tested as well. Paired t test was used to compare scores between baseline and follow‐up. In total, 45 participants (94%) completed the follow‐up. No significant differences were observed on fatigue or QOL when comparing baseline and follow‐up. Mean maximal oxygen uptake increased from 27.2 to 33.6 ml O2 · kg −1 ·min −1 ( p < 0.001). Handgrip strength ( p = 0.01) and the 30‐s chair‐stand test ( p < 0.001) improved as well. No changes were found regarding levels of fatigue and QOL. However, we observed a significant increase in the physical capacity. Our observations call for further studies investigating the effects of non‐pharmacological approaches in patients with MPN.