Histogram analysis of volume-based apparent diffusion coefficient in breast cancer. (November 2017)

• Record Type: Journal Article
• Authors: Park, Ga Eun; Kim, Sung Hun; Kim, Eun Jeong; Kang, Bong Joo; Park, Mi Sun
• Is Part Of: Acta radiologica. Volume 58:Number 11(2017:Nov.)
• Page Start: 1294
• Page End: 1302
• Publication Date: 2017-11
• Subjects: Breast cancer -- magnetic resonance imaging (MRI) -- diffusion-weighted imaging (DWI) -- apparent diffusion coefficient (ADC); Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185117694507
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: Breast cancer is a heterogeneous disease. Recent studies showed that apparent diffusion coefficient (ADC) values have various association with tumor aggressiveness and prognosis. Purpose: To evaluate the value of histogram analysis of ADC values obtained from the whole tumor volume in invasive ductal cancer (IDC) and ductal carcinoma in situ (DCIS). Material and Methods: This retrospective study included 201 patients with confirmed DCIS (n = 37) and IDC (n = 164). The IDC group was divided into two groups based on the presence of a DCIS component: IDC–DCIS (n = 76) and pure IDC (n = 88). All patients underwent preoperative breast magnetic resonance imaging (MRI) with diffusion-weighted images at 3.0 T. Histogram parameters of cumulative ADC values, skewness, and kurtosis were calculated and statistically analyzed. Results: The differences between DCIS, IDC–DCIS, and pure IDC were significant in all percentiles of ADC values, in descending order of DCIS, IDC–DCIS, and pure IDC. IDC showed significantly lower ADC values than DCIS, and ADC50 was the best indicator for discriminating IDC from DCIS, with a threshold of 1.185 × 10 –3 mm 2 /s (sensitivity of 82.9%, specificity of 75.7%). However, multivariate analysis of obtained ADC values showed no significant differences between DCIS, IDC–DCIS, and pure IDC ( P > 0.05). Conclusion: Volume-based ADC values showed association with heterogeneity of breast cancer. However, there was no additional diagnostic performance in histogram analysis for differentiating between DCIS, IDC–DCIS, and pure IDC.