Risk stratification of high‐risk metastatic neuroblastoma: A report from the HR‐NBL‐1/SIOPEN study. Issue 11 (17th July 2018)

• Record Type: Journal Article
• Authors: Morgenstern, Daniel A.; Pötschger, Ulrike; Moreno, Lucas; Papadakis, Vassilios; Owens, Cormac; Ash, Shifra; Pasqualini, Claudia; Luksch, Roberto; Garaventa, Alberto; Canete, Adela; Elliot, Martin; Wieczorek, Aleksandra; Laureys, Geneviève; Kogner, Per; Malis, Josef; Ruud, Ellen; Beck‐Popovic, Maja; Schleiermacher, Gudrun; Valteau‐Couanet, Dominique; Ladenstein, Ruth
• Is Part Of: Pediatric blood & cancer. Volume 65:Issue 11(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-07-17
• Subjects: lactate dehydrogenase -- metastatic -- neuroblastoma -- relapse -- risk stratification -- ultra‐high risk; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.27363
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Background: Risk stratification is crucial to treatment decision‐making in neuroblastoma. This study aimed to explore factors present at diagnosis affecting outcome in patients aged ≥18 months with metastatic neuroblastoma and to develop a simple risk score for prognostication. Procedure: Data were derived from the European high‐risk neuroblastoma 1 (HR‐NBL1)/International Society for Paediatric Oncology European Neuroblastoma (SIOPEN) trial with analysis restricted to patients aged ≥18 months with metastatic disease and treated prior to the introduction of immunotherapy. Primary endpoint was 5‐year event‐free survival (EFS). Prognostic factors assessed were sex, age, tumour MYCN amplification (MNA) status, serum lactate dehydrogenase (LDH)/ferritin, primary tumour and metastatic sites. Factors significant in univariate analysis were incorporated into a multi‐variable model and an additive scoring system developed based on estimated log‐cumulative hazard ratios. Results: The cohort included 1053 patients with median follow‐up 5.5 years and EFS 27 ± 1%. In univariate analyses, age; serum LDH and ferritin; involvement of bone marrow, bone, liver or lung; and >1 metastatic system/compartment were associated with worse EFS. Tumour MNA was not associated with worse EFS. A multi‐variable model and risk score incorporating age (>5 years, 2 points), serum LDH (>1250 U/L, 1 point) and number of metastatic systems (>1, 2 points) were developed. EFS was significantly correlated with risk score: EFS 52 ± 9% for score = 0 versus 6 ± 3% for score = 5 ( P < 0.0001). Conclusions: A simple score can identify an "ultra‐high risk" (UHR) cohort (score = 5) comprising 8% of patients with 5‐year EFS <10%. These patients appear not to benefit from induction therapy and could potentially be directed earlier to alternative experimental therapies in future trials.