Prognostic significance of interim 18F‐fluorodeoxyglucose positron emission tomography–computed tomography volumetric parameters in metastatic or recurrent gastric cancer. Issue 5 (10th December 2017)

• Record Type: Journal Article
• Authors: Lee, Suk‐young; Seo, Hyo Jung; Kim, Sungeun; Eo, Jae Seon; Oh, Sang Cheul
• Is Part Of: Asia-Pacific journal of clinical oncology. Volume 14:Issue 5(2018)
• Page Start: e302
• Page End: e309
• Publication Date: 2017-12-10
• Subjects: advanced gastric cancer -- fluoropyrimidine -- interim 18F‐FDG PET/CT -- prognosis -- volumetric parameter; Oncology -- Pacific Area -- Periodicals; Cancer -- Treatment -- Pacific Area -- Periodicals; Cancer -- Pacific Area -- Periodicals; Cancer -- Treatment -- Periodicals; 616.9940095
• DOI: 10.1111/ajco.12833
• Languages: English
• ISSNs: 1743-7555

Abstract

Abstract: Aim: To evaluate the prognostic role of interim analysis of 18F‐fluorodeoxyglucose (FDG) positron emission tomography–computed tomography (PET/CT) volumetric parameters in patients with recurrent or metastatic advanced gastric cancer (AGC) treated with fluoropyrimidine‐based palliative chemotherapy. Methods: Forty‐four patients who underwent baseline and interim PET/CT scanning during palliative chemotherapy were analyzed retrospectively. Initial and change of metabolic parameters (MP) – metabolic tumor volume (MTV), tumor lesion glycolysis (TLG) and maximum and mean standardized uptake values (SUV) were measured with PET/CT. Metabolic change was measured by ∆MP (%) = (MPinterim − MPinitial )/MP initial × 100. Independent t ‐test was employed to compare values of initial, interim and change of metabolic parameters between each response group. Log‐rank test was employed for univariate analysis, and multivariate analysis was performed using the Cox proportional hazards regression model to determine independently significant prognostic factors. Results: Reduced percentage values of maximum and mean SUV on interim PET/CT and initial values of volumetric parameters (MTV and TLG) were significant predicting factors to response to fluoropyrimidine‐based palliative chemotherapy. The decreased percentage values of metabolic parameters as well as maximum and mean SUV with receiver operating characteristic (ROC) curve determined cut‐off points were significant prognostic factors for overall survival and progression‐free survival in univariate and multivariate analyses. Conclusion: Measurement of metabolic decrease of volumetric parameters by interim PET/CT analysis is useful to determine the prognosis of patients with recurrent or metastatic AGC.