SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV‐2. Issue 5 (26th September 2018)

• Record Type: Journal Article
• Authors: Schmitt, Kimberly; Curlin, James; Kumar, Dipu Mohan; Remling‐Mulder, Leila; Feely, Stephanie; Stenglein, Mark; O'Connor, Shelby; Marx, Preston; Akkina, Ramesh
• Is Part Of: Journal of medical primatology. Volume 47:Issue 5(2018)
• Page Start: 298
• Page End: 301
• Publication Date: 2018-09-26
• Subjects: cross‐species transmission of SIV -- modeling SIV evolution using humanized mice -- SIV evolution into HIV using humanized mice -- SIVsm evolution into HIV‐2 -- viral evolution of SIVsm into HIV‐2 -- SIV pathogenesis in humanized mice; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12380
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: How SIV progenitors evolved into deadly HIV‐1 and HIV‐2 following initial cross‐species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV‐2. Increased viral virulence to human CD4 + T cells and adaptive genetic changes were observed during serial passages.