Intraoperative fluorescence imaging in thoracic surgery. Issue 2 (11th August 2018)

• Record Type: Journal Article
• Authors: Newton, Andrew D.; Predina, Jarrod D.; Nie, Shuming; Low, Philip S.; Singhal, Sunil
• Other Names: Karakousis Giorgos guestEditor.; Bouvet Michael guestEditor.
• Is Part Of: Journal of surgical oncology. Volume 118:Issue 2(2018)
• Page Start: 344
• Page End: 355
• Publication Date: 2018-08-11
• Subjects: indocyanine green (ICG) -- intraoperative fluorescence imaging (IFI) -- near‐infrared (NIR) fluorescence imaging -- OTL38 -- thoracic surgery; Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.25149
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract : Intraoperative fluorescence imaging (IFI) can improve real‐time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow ® ) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor‐targeted near‐infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.