Injectable Enzymatically Cross‐linked Hydrogels with Light‐Controlled Degradation Profile. Issue 18 (12th July 2018)

• Record Type: Journal Article
• Authors: Cheng, Yilong; He, Chaoliang; Ren, Kaixuan; Rong, Yan; Xiao, Chunsheng; Ding, Jianxun; Zhuang, Xiuli; Chen, Xuesi
• Is Part Of: Macromolecular rapid communications. Volume 39:Issue 18(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-07-12
• Subjects: enzymatic cross‐linking -- injectable hydrogels -- photo‐degradation -- poly(ethylene glycol); Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.201800272
• Languages: English
• ISSNs: 1022-1336

Abstract

Abstract: An advanced hydrogel that features facile formation and injectability as well as light‐controlled degradation profile is reported here. By modifying 4‐arm poly(ethylene glycol) (4‐arm PEG) with 2‐nitrobenzyl (NB) and phenol, the 4‐arm PEG precursor solutions could form enzymatically cross‐linked hydrogels in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2 O2 ). The gelation time, mechanical strength, and porous structure could be simply tuned by the concentration of HRP and H2 O2 . Moreover, the hydrogels underwent controlled degradation under UV light irradiation via photo‐cleavage reaction of the NB ester bond. The hydrogels exhibited negligible cytotoxicity toward mouse fibroblast L929 cells in vitro and can be manipulated through injection in vivo. Abstract : An advanced hydrogel featuring facile formation and light‐controlled degradation is reported here. A solution of 4‐arm poly(ethylene glycol) derivative undergoes sol–gel transition in the presence of horseradish peroxidase and H2 O2, and degradation of the hydrogel can be easily controlled by UV light through cleavage of the 2‐nitrobenzyl ester bond.