Empirical data in support of a skin notation for methyl chloride. Issue 8 (3rd August 2018)

• Record Type: Journal Article
• Authors: Gaskin, Sharyn; Thredgold, Leigh; Heath, Linda; Pisaniello, Dino; Logan, Michael; Baxter, Christina
• Is Part Of: Journal of occupational and environmental hygiene. Volume 15:Issue 8(2018)
• Page Start: 569
• Page End: 572
• Publication Date: 2018-08-03
• Subjects: Chloromethane -- dermal -- in vitro -- methyl chloride -- skin notation; Industrial hygiene -- Periodicals; Environmental health -- Periodicals; Medicine, Industrial -- Periodicals; Occupational Health -- Periodicals; Environmental Exposure -- Periodicals; Environmental Health -- Periodicals; Occupational Exposure -- Periodicals; Hygiène industrielle -- Périodiques; Hygiène du milieu -- Périodiques; Médecine du travail -- Périodiques; 613.62
• DOI: 10.1080/15459624.2018.1470636
• Languages: English
• ISSNs: 1545-9624

Abstract

Abstract: This article presents the first empirical experimental data on the skin absorption of methyl chloride gas using an in vitro technique and human skin. Methyl chloride is a commonly used industrial agent that is known to be an inhalational hazard but is also reported to be absorbed through human skin in amounts that contribute substantially to systemic intoxication. As a result, is has been assigned a skin notation by the ACGIH. Other than predictive models, there is a general paucity of experimental data on the skin absorption of methyl chloride and therefore a distinct lack of empirical evidence in the open literature to support the assignment of a skin notation for this chemical. This study found that methyl chloride permeates through human epidermis when exposed at high atmospheric concentrations within relatively short timeframes. Therefore, providing important initial empirical evidence in support of the assignment of a skin notation.