Long noncoding RNA H19 inhibits the proliferation of fetal liver cells and the Wnt signaling pathway. Issue 4 (8th February 2016)

• Record Type: Journal Article
• Authors: Wang, Shaobing; Wu, Xia; Liu, Yan; Yuan, Jihang; Yang, Fu; Huang, Jinfeng; Meng, Qingyang; Zhou, Chuanchuan; Liu, Feng; Ma, Jinzhao; Sun, Shuhan; Zheng, Jiasheng; Wang, Fang
• Editors: Mantei, Ned
• Is Part Of: FEBS letters. Volume 590:Issue 4(2016)
• Page Start: 559
• Page End: 570
• Publication Date: 2016-02-08
• Subjects: ChIP‐seq -- H19 -- hnRNP U -- liver development -- long noncoding RNA -- Wnt/β‐catenin signaling pathway; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12078
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : In this study, we found that H19 is the most strongly differentially expressed long noncoding RNA (lncRNA) during liver development. H19 may inhibit the proliferation of fetal liver cells by blocking the interaction between heterogeneous nuclear ribonucleoprotein (hnRNP) U and actin, which results in gene transcriptional repression. Based on ChIP‐seq analysis, we found that genes involved in the Wnt signaling pathway are enriched among hnRNP U‐binding genes. Further investigation demonstrated that hnRNP U has opposing effects on cell proliferation and Wnt/β‐catenin signaling pathway activity compared to H19 and that hnRNP U is very important in this process. Abstract :