Connectome to behaviour: modelling Caenorhabditis elegans at cellular resolution. (10th September 2018)

• Record Type: Journal Article
• Authors: Larson, Stephen D.; Gleeson, Padraig; Brown, André E. X.
• Is Part Of: Philosophical transactions. Volume 373:Number 1758(2018)
• Publication Date: 2018-09-10
• Subjects: nervous system -- open data -- simulation -- Caenorhabditis elegans -- connectome -- behaviour; Biology -- Periodicals; Science -- Periodicals; 570
• DOI: 10.1098/rstb.2017.0366
• Languages: English
• ISSNs: 0962-8436

Abstract

Abstract : It has been 30 years since the 'mind of the worm' was published in Philosophical Transactions B (White et al . 1986 Phil. Trans. R. Soc. Lond. B 314, 1–340). Predicting Caenorhabditis elegans ' behaviour from its wiring diagram has been an enduring challenge since then. This special theme issue of Philosophical Transactions B combines research from neuroscientists, physicists, mathematicians and engineers to discuss advances in neural activity imaging, behaviour quantification and multiscale simulations, and how they are bringing the goal of whole-animal modelling at cellular resolution within reach. This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. elegans at cellular resolution'.