Serum carbohydrate antigen 153 and renal function in patients with type 2 diabetes mellitus. Issue 7 (27th April 2018)

• Record Type: Journal Article
• Authors: Peng, You‐Fan; Lin, Hao; Han, Man‐Man; Li, Ling
• Is Part Of: Journal of clinical laboratory analysis. Volume 32:Issue 7(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-04-27
• Subjects: glomerular filtration rate -- serum carbohydrate antigen 153 -- type 2 diabetes mellitus; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.22461
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract : Objective: The aim of our study was to investigate the correlation between serum carbohydrate antigen 153 (CA153) and renal function in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 184 patients with T2DM were included, and renal function was assessed by the modification of diet in renal disease (MDRD) formula adjusted coefficient of the Chinese people. Results: Serum CA153 concentrations were positively correlated with blood glucose (BG) and glycated hemoglobin (HbA1c) ( r = .204, P = .005; r = .165, P = .025) in patients with T2DM. There was a negative correlation between serum CA153 and estimated glomerular filtration rate (GFR) ( r = −.229, P = .002) in whole patients with T2DM; similarly, the correlations were observed in both women and men ( r = −.228, P = .028 for women, r = −.231, P = .028 for men). Multiple linear regression analysis suggested that serum CA153 was still significantly correlated with estimated GFR (beta = −0.286, P < .001). Conclusions: Serum CA153 is negatively correlated with estimated GFR in patients with T2DM, and serum CA153 may be a potentially useful clinical biomarker to assess renal function in the study population.