Gene therapy in inherited retinal degenerative diseases, a review. (3rd September 2018)

• Record Type: Journal Article
• Authors: Takahashi, Vitor K. L.; Takiuti, Júlia T.; Jauregui, Ruben; Tsang, Stephen H.
• Is Part Of: Ophthalmic genetics. Volume 39:Number 5(2018)
• Page Start: 560
• Page End: 568
• Publication Date: 2018-09-03
• Subjects: Adeno-associated virus -- gene therapy -- inherited retinal diseases; Eye -- Diseases -- Genetic aspects -- Periodicals; Eye Diseases -- genetics -- Periodicals; Eye Diseases -- in infancy & childhood -- Periodicals; 617.7
• DOI: 10.1080/13816810.2018.1495745
• Languages: English
• ISSNs: 1381-6810

Abstract

ABSTRACT: Hereditary diseases of the retina represent a group of diseases with several heterogeneous mutations that have the common end result of progressive photoreceptor death leading to blindness. Retinal degenerations encompass multifactorial diseases such as age-related macular degeneration, Leber congenital amaurosis, Stargardt disease, and retinitis pigmentosa. Although there is currently no cure for degenerative retinal diseases, ophthalmology has been at the forefront of the development of gene therapy, which offers hope for the treatment of these conditions. This article will explore an overview of the clinical trials of gene supplementation therapy for retinal diseases that are underway or planned for the near future.