A new12-membered lactone from the stems of Ficus auriculata. Issue 19 (2nd October 2018)

• Record Type: Journal Article
• Authors: Shao, Tai-Ming; Zheng, Cai-Juan; Li, Xiao-Bao; Chen, Guang-Ying; Song, Xiao-Ping; Han, Chang-Ri
• Is Part Of: Natural product research. Volume 32:Issue 19(2018)
• Page Start: 2268
• Page End: 2273
• Publication Date: 2018-10-02
• Subjects: Ficus auriculata -- lactone -- antibacterial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1405415
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new lactone ficusine D (1 ), together with six known compounds (2 –7 ) were isolated from the stems of the Ficus auriculata . The new compound1 was a rare 12-membered lactone containing a quinone ring skeleton. The structure of the1 was elucidated by comprehensive spectroscopic data. The relative and absolute configurations of1 were elucidated by the ROESY analysis and biogenesis pathway. All compounds were evaluated for their antibacterial activities against six pathogenic bacteria in vitro . Compounds6 and7 exhibited potent antibacterial activities against Bacillus cereus with the MIC values of 2.5 and 5 μM, respectively. Abstract :