A pair of enantiomeric 5-oxabicyclic[4.3.0]lactam derivatives and one new polyketide from the marine-derived fungus Penicillium griseofulvum. Issue 19 (2nd October 2018)

• Record Type: Journal Article
• Authors: Yang, Jian-Kun; Zhang, Bin; Gao, Tong; Yang, Meng-Yue; Zhao, Guo-Zheng; Zhu, Hua-Jie; Liu, Li; Cao, Fei
• Is Part Of: Natural product research. Volume 32:Issue 19(2018)
• Page Start: 2366
• Page End: 2369
• Publication Date: 2018-10-02
• Subjects: Penicillium griseofulvum -- bicyclic lactam -- polyketide -- antibacterial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1410815
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A pair of enantiomeric 4-oxabicyclic[4.3.0]lactam derivatives, (+)- and (−)-penicilactam A (1 ), and one new polyketide derivative penicitrinone F (2 ) were isolated from the marine-derived fungus Penicillium griseofulvum GT-10. Their structures and absolute configurations were elucidated through extensive spectroscopic analyses combined with the calculated ECD spectra. Penicitrinone F (2 ) had moderate inhibitory activity towards Bacillus subtilis with a MIC value of 6.3 μM. Abstract :