Acetylsalicylic Acid Treatment Improves Differentiation and Immunomodulation of SHED. (January 2015)

• Record Type: Journal Article
• Authors: Liu, Y.; Chen, C.; Liu, S.; Liu, D.; Xu, X.; Chen, X.; Shi, S.
• Is Part Of: Journal of dental research. Volume 94:Number 1(2015:Jan.)
• Page Start: 209
• Page End: 218
• Publication Date: 2015-01
• Subjects: mesenchymal stem cells -- deciduous teeth -- cell therapy -- telomerase -- Fas ligand -- Wnt pathway; Dentistry -- Periodicals; Dentistry -- Social aspects -- Periodicals; Dentistry -- Periodicals; Research -- Periodicals; 617.6005
• DOI: 10.1177/0022034514557672
• Languages: English
• ISSNs: 0022-0345

Abstract

Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration and autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated osteogenic differentiation and immunomodulation. Mechanistically, ASA treatment upregulates the telomerase reverse transcriptase (TERT)/Wnt/β-catenin cascade, leading to improvement of SHED-mediated bone regeneration, and also upregulates TERT/FASL signaling, leading to improvement of SHED-mediated T-cell apoptosis and ameliorating disease phenotypes in dextran sodium sulfate–induced colitis mice. These data indicate that ASA treatment is a practical approach to improving SHED-based cell therapy.