A new amino amidine derivative from the wood-decaying fungus Xylaria cf. cubensis SWUF08-86. Issue 19 (2nd October 2018)

• Record Type: Journal Article
• Authors: Sawadsitang, Sasiphimol; Suwannasai, Nuttika; Mongkolthanaruk, Wiyada; Ahmadi, Peni; McCloskey, Sirirath
• Is Part Of: Natural product research. Volume 32:Issue 19(2018)
• Page Start: 2260
• Page End: 2267
• Publication Date: 2018-10-02
• Subjects: Xylariaceae -- Xylaria cf. cubensis -- secondary metabolites -- amino amidine -- cyclic dipeptide; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1405414
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The secondary metabolites of Xylaria cf. cubensis SWUF08-86 fungus were investigated, and the chromatographic separation of the crude extracts yielded seventeen compounds. The structure elucidation by spectroscopic analysis including 1D and 2D NMR and the comparison of these data with literature, along with HREIMS spectrometry, revealed one new amino amidine derivative (1 ), together with five known simple cyclic dipeptide analogs, diketopiperazines (2 –6 ) and eleven other known compounds, including one hemi -cycline (10 ), three aromatic derivatives (11 –13 ), one sesquiterpene (14 ) and three sterols (15 –17 ). The isolated compounds were screened for anticancer and anti-pathogenic bacterial and fungal activities. Based on this work, Xylaria cf. cubensis SWUF08-86 has proven to be a diverse secondary metabolites producer. Abstract :