New coumarin from the roots of Prangos pabularia. Issue 19 (2nd October 2018)

• Record Type: Journal Article
• Authors: Numonov, Sodik; Bobakulov, Khayrulla; Numonova, Mukhabbat; Sharopov, Farukh; Setzer, William N.; Khalilov, Qosimjon; Begmatov, Nurmirza; Habasi, Maidina; Aisa, Haji Akber
• Is Part Of: Natural product research. Volume 32:Issue 19(2018)
• Page Start: 2325
• Page End: 2332
• Publication Date: 2018-10-02
• Subjects: Prangos pabularia -- coumarins -- furanocoumarins -- yuganin A -- NMR -- B16 melanoma cells; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1413558
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The new coumarin1, yuganin A (7-methoxy-8-((1 S, 2 S )-1, 2, 3-trihydroxy-3-methylbutyl)-2 H -chromen-2-one) along with nine known coumarins, heraclenol 3′- O -β-D-glucopyranoside (2 ), oxypeucedanin hydrate 3′- O -β-D-glucopyranoside (3 ), heraclenol (4 ), oxypeucedanin hydrate (5 ), osthole (6 ), oxypeucedanin (7 ), heraclenin (8 ), isoimperatorin (9 ), imperatorin (10 ) and the disaccharide sucrose (11 ), have been isolated from the roots of Prangos pabularia, and the structures of these isolated compounds were elucidated by spectroscopic means, especially, UV, HR-ESIMS, and 1D and 2D NMR spectroscopy. Furthermore, the anti-melanogenic effect of yuganin A and its inhibitory effect on B16 cells were evaluated. Yuganin A may be useful in the treatment of hyperpigmentation and as a skin-whitening agent in the cosmetics industry. Abstract :