A new C-glycosyl flavone and a new neolignan glycoside from Passiflora edulis Sims peel. Issue 19 (2nd October 2018)

• Record Type: Journal Article
• Authors: Hu, Yue; Jiao, Lin; Jiang, Min-Hong; Yin, Sheng; Dong, Pan; Zhao, Zhi-Min; Yang, De-Po; Ho, Pei-Tsai; Wang, Dong-Mei
• Is Part Of: Natural product research. Volume 32:Issue 19(2018)
• Page Start: 2312
• Page End: 2318
• Publication Date: 2018-10-02
• Subjects: Passiflora edulis Sims peel -- C-glycosyl flavone -- neolignan glycoside; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1410809
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new C -glycosyl flavone, Chrysin-8- C -(2″- O - β -6-deoxy-glucopyranosyl)- β -D-glucopyranoside (1 ), a new neolignan glycoside, citrusin G (2 ), as well as 15 known compounds (3 –17 ) were isolated from the peel of Passiflora edulis Sims. The structure determinations were primarily based on comprehensive spectroscopic analyses, and the absolute configuration of2 were unequivocally determined by the CD experiment and chemical transformation. Compound1 represents the rare examples of the flavonoid featuring a deoxy glucose sugar moiety. Compounds5, 7 and9 exhibited moderate inhibitory effects on nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells, with IC50 values of 34.92, 16.12 and 26.67 μM, respectively. Abstract :