The effect of oxidative stress on the progression of Hashimoto's thyroiditis. (8th August 2018)

• Record Type: Journal Article
• Authors: Ates, Ihsan; Arikan, Mehmet Fettah; Altay, Mustafa; Yilmaz, Fatma Meric; Yilmaz, Nisbet; Berker, Dilek; Guler, Serdar
• Is Part Of: Archives of physiology and biochemistry. Volume 124:Number 4(2018)
• Page Start: 351
• Page End: 356
• Publication Date: 2018-08-08
• Subjects: Autoimmune thyroiditis -- overall oxidative stress -- overt hypothyroidism -- subclinical hypothyroidism; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2017.1408660
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Objective: We aimed to investigate the effects of oxidative stress in the pathogenesis and progression of Hashimoto's thyroiditis (HT). Methods: Forty euthyroid and 40 subclinical hypothyroid patients older than 18 years and not yet had received treatment were enrolled in the study. Results: In the 9 months follow-up, 14 of the HT patients developed overt hypothyroidism. The mean total oxidant status (TOS) and oxidative stress index (OSI) were higher in patients who developed overt hypothyroidism than those who did not ( p < .001). And no significant difference was found between the two groups in terms of paraoxanase-1 and arylesterase ( p > .05). Multivariable Cox regression model showed thyroid stimulating hormone level (HR = 1.348, p < .001), free-thyroxine level (HR = 0.481, p = .017) and OSI ratio (HR = 2.349, p < .001) to be independent predictors of development of overt hypothyroidism. OSI level, being over 2.96 with 92.9% sensitivity and 62.5% specificity, predicts the risk of hypothyroidism. Conclusion: Oxidative stress may be an effective risk factor in the development of overt hypothyroidism in HT.