Effect of oral supplementation of composite leaf extract of medicinal plants on biomarkers of oxidative stress in induced diabetic Wistar rats. (8th August 2018)

• Record Type: Journal Article
• Authors: Tiwari, Brahm Kumar; Abidi, Abu Baker; Rizvi, Syed Ibrahim; Pandey, Kanti Bhooshan
• Is Part Of: Archives of physiology and biochemistry. Volume 124:Number 4(2018)
• Page Start: 361
• Page End: 366
• Publication Date: 2018-08-08
• Subjects: Diabetes -- oxidative stress -- medicinal plants -- composite extract -- antioxidant; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2017.1411369
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Present study was conducted to evaluate the effect of oral supplementation of composite extract of leaves (CLE) of four medicinal plants; Aegle marmelos, Ocimum sanctum, Murraya koenigii and Azadirachta indica on markers of oxidative stress in brain tissues of alloxan-induced diabetic rats in vivo . Enhanced lipid peroxidation, protein oxidation and reduced antioxidative defence systems were measured in brain tissues of diabetic rats. Supplementation of CLE, once in a day for 35 days significantly ( p < .05) protected the peroxidation of lipid, oxidation of protein and ameliorated the antioxidant defence in brain tissue of diabetic rats. It was observed that the insulin-like effect of CLE was dose dependent; higher effect at higher doses. The results of the study suggest that supplementation CLE may provide an overall homeostasis and significant neuro-protection through rescuing brain cells from oxidative abuse and accelerating brain antioxidative defence during advanced stage of hyperglycaemia.