Contribution of low- and high-flux capillaries to slow hemodynamic fluctuations in the cerebral cortex of mice. Issue 8 (August 2016)

• Record Type: Journal Article
• Authors: Li, Baoqiang; Lee, Jonghwan; Boas, David A; Lesage, Frederic
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 36:Issue 8(2016)
• Page Start: 1351
• Page End: 1356
• Publication Date: 2016-08
• Subjects: Capillaries -- OCT -- flux -- low frequency -- oscillation; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1177/0271678X16649195
• Languages: English
• ISSNs: 0271-678X

Abstract

We employed optical coherence tomography to measure cerebral cortical capillary red blood cell (RBC) flux in mice. The results suggest that baseline-flux weakly depends on cortical depth. Furthermore, under hypercapnia, low baseline-flux capillaries exhibit greater flux increases while the higher ones saturate, resulting in RBC-flux homogenization. Power-spectrum analysis indicates that higher flux capillaries saw greater flux variability in the low-frequency range (0.01–0.1 Hz) both at baseline and during hypercapnia. These results suggest that lower baseline-flux capillaries have more reserve to deliver oxygen with increased blood flow; but higher ones more strongly impact the low-frequency fluctuations associated with BOLD fMRI measurements of resting state functional connectivity.