Experimental hypertension increases spontaneous intracerebral hemorrhages in a mouse model of cerebral amyloidosis. Issue 2 (February 2016)

• Record Type: Journal Article
• Authors: Passos, Giselle F; Kilday, Kelley; Gillen, Daniel L; Cribbs, David H; Vasilevko, Vitaly
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 36:Issue 2(2016)
• Page Start: 399
• Page End: 404
• Publication Date: 2016-02
• Subjects: Alzheimer's disease -- cerebral amyloid angiopathy -- hypertension -- intracerebral hemorrhage -- risk factors; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1177/0271678X15606720
• Languages: English
• ISSNs: 0271-678X

Abstract

Hypertension and cerebral amyloid angiopathy (CAA) are major risk factors for intracerebral hemorrhage (ICH); however the mechanisms of interplay between the two are not fully understood. We investigated the effect of hypertension in a transgenic mouse model with Alzheimer's-like pathology (Tg2576) treating them with angiontensin II and L-N G -nitroarginine methyl ester. A similar increase in systolic blood pressure was observed in both Tg2576 and control mice; however Tg2576 mice developed signs of stroke with a markedly shorter latency. Cerebral deposition of amyloid beta promotes the hypertension-induced ICH, thus supporting the notion that hypertension is a risk factor for ICH among patients with CAA.