Reduction of a platinum(iv) prodrug model by sulfur containing biological reductants: computational mechanistic elucidation. Issue 74 (30th August 2018)

• Record Type: Journal Article
• Authors: Chipman, Antony; Yates, Brian F.; Canty, Allan J.; Ariafard, Alireza
• Is Part Of: Chemical communications. Volume 54:Issue 74(2018)
• Page Start: 10491
• Page End: 10494
• Publication Date: 2018-08-30
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc05682j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : In order for the usuall -Cys zwitterion to reduce Pt IV, it is first required to tautomerise into its unusual form. Abstract : A Pt IV prodrug needs to be reduced to Pt II by a biomolecule in order to show efficacy. Among biomolecules, those containing anl -Cys residue have the highest potential to be involved in reduction. Tautomerisation from HSCH2 CH(NH3 + )CO2 − to the unusual zwitterion form − SCH2 CH(NH3 + )CO2 H is the prerequisite forl -Cys to become a potent reductant at a low pH.