Convenient approach to polyoxygenated dibenzo[c, e]pyrrolo[1, 2-a]azepines from donor–acceptor cyclopropanes. Issue 19 (31st August 2018)

• Record Type: Journal Article
• Authors: Boichenko, Maksim A.; Ivanova, Olga A.; Andreev, Ivan A.; Chagarovskiy, Alexey O.; Levina, Irina I.; Rybakov, Victor B.; Skvortsov, Dmitriy A.; Trushkov, Igor V.
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 19(2018)
• Page Start: 2829
• Page End: 2834
• Publication Date: 2018-08-31
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c8qo00742j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A convenient approach to polyoxygenated tetrahydrodibenzo[ c, e ]pyrrolo[1, 2- a ]azepines from the donor–acceptor cyclopropanes has been developed. Abstract : A short convenient approach to polyoxygenated tetrahydrodibenzo[ c, e ]pyrrolo[1, 2- a ]azepines from the donor–acceptor cyclopropanes was developed. A simple synthetic sequence involves: (a) cyclopropane ring opening with azide ion and Krapcho dealkoxycarbonylation; (b) azide-to-imine transformation followed by imine reduction; (c) the oxidative cyclization of 5-aryl-1-benzylpyrrolidin-2-ones, the key intermediates for this approach.