An "all-in-one" antitumor and anti-recurrence/metastasis nanomedicine with multi-drug co-loading and burst drug release for multi-modality therapy. Issue 36 (7th August 2018)

• Record Type: Journal Article
• Authors: Yang, Ji-Chun; Shang, Yue; Li, Yu-Hao; Cui, Yu; Yin, Xue-Bo
• Is Part Of: Chemical science. Volume 9:Issue 36(2018)
• Page Start: 7210
• Page End: 7217
• Publication Date: 2018-08-07
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8sc02305k
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A simple multi-modality therapy with multi-drug co-loading and burst drug release for a high curative effect and anti-recurrence/metastasis was reported. Abstract : Drug-loading often suffers from tedious procedures, limited loading efficiency, slow release, and therefore a low curative effect. Cancer easily recurs and metastasizes even after a solid tumor is removed. Herein, we report a simple strategy with multi-drug co-loading and burst drug release for a high curative effect and anti-recurrence/metastasis. CuS nanoparticles, protoporphyrin IX, and doxorubicin were added to the precursors of ZIF-8 with one-pot co-loading during the formation of ZIF-8 for chemo-, photothermal-, and photodynamic-therapy to eliminate solid tumors. Negative CpG, as a kind of immune adjuvant, was adsorbed on the positive surface of ZIF-8 to inhibit the recurrence and metastasis of tumors with its long-term immune response. Precision treatment with one-pot multi-drug co-loading, controllable drug delivery, and multi-modality therapy may be anticipated by this versatile strategy.