Anaplastic Ependymoma With Ganglionic Differentiation: Report of a Rare Case and Implications in Diagnosis. (October 2017)

• Record Type: Journal Article
• Authors: Rao, Shilpa; Ravindra, Niveditha; Sadashiva, Nishanth; Indira Devi, Bhagavatula; Santosh, Vani
• Is Part Of: International journal of surgical pathology. Volume 25:Number 7(2017)
• Page Start: 644
• Page End: 647
• Publication Date: 2017-10
• Subjects: ependymoma -- ganglion -- MELK -- stem cell; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896917710716
• Languages: English
• ISSNs: 1066-8969

Abstract

Ependymomas are glial neoplasms with rare cases exhibiting neuronal differentiation. We describe a case of spinal anaplastic ependymoma with ganglionic differentiation in a 28-year-old woman. The ganglionic component was labeled by synaptophysin, whereas the rest of the tumor showed features of an anaplastic ependymoma. Stem cell marker MELK was noted to stain both the neoplastic ependymal and ganglionic components, possibly suggesting a stem cell/progenitor origin for the tumor with subsequent divergent differentiation.