Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application. Issue 37 (13th July 2018)

• Record Type: Journal Article
• Authors: Chung, Lai-Hon; Ng, Sze-Wing; Yeung, Chi-Fung; Shek, Hau-Lam; Tse, Sheung-Ying; Lo, Hoi-Shing; Chan, Siu-Chung; Tse, Man-Kit; Yiu, Shek-Man; Wong, Chun-Yuen
• Is Part Of: Dalton transactions. Volume 47:Issue 37(2018)
• Page Start: 12838
• Page End: 12842
• Publication Date: 2018-07-13
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c8dt02408a
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : The first examples of metal–indolizinone complexes prepared by Ru-assisted activation of pyridine-tethered alkynes exhibit moderate cytotoxicity against several human cancer cell lines. Abstract : The two series of ruthenium–indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental–theoretical investigation suggests an unconventional 5- endo-dig cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.