Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids. Issue 36 (5th September 2018)

• Record Type: Journal Article
• Authors: Schettini, R.; Costabile, C.; Della Sala, G.; Buirey, J.; Tosolini, M.; Tecilla, P.; Vaccaro, M. C.; Bruno, I.; De Riccardis, F.; Izzo, I.
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 36(2018)
• Page Start: 6708
• Page End: 6717
• Publication Date: 2018-09-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob01522h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Five new cyclic peptoids containing (2 S, 4 R )-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed "submonomer/monomer" approach. Abstract : Five new cyclic peptoids containing (2 S, 4 R )-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed "submonomer/monomer" approach. Alkali metal cation affinities and ion transport activities were assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of hydroxyproline residues afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities on selected human cancer cell lines.