Choline ionic liquid enhances the stability of Herceptin® (trastuzumab). Issue 75 (4th September 2018)
- Record Type:
- Journal Article
- Title:
- Choline ionic liquid enhances the stability of Herceptin® (trastuzumab). Issue 75 (4th September 2018)
- Main Title:
- Choline ionic liquid enhances the stability of Herceptin® (trastuzumab)
- Authors:
- Reslan, Mouhamad
Ranganathan, Vijayaraghavan
Macfarlane, Douglas R.
Kayser, Veysel - Abstract:
- Abstract : Choline dihydrogen phosphate (CDHP) suppresses trastuzumab unfolding and early-stage aggregation Abstract : We investigated the effect of an emerging biocompatible ionic liquid, choline dihydrogen phosphate (CDHP), on the stability of high-concentration formulations of Herceptin® (trastuzumab). Our results show that CDHP significantly suppresses unfolding and aggregation of trastuzumab, demonstrating great promise as an additive in the development of stable therapeutic antibody formulations.
- Is Part Of:
- Chemical communications. Volume 54:Issue 75(2018)
- Journal:
- Chemical communications
- Issue:
- Volume 54:Issue 75(2018)
- Issue Display:
- Volume 54, Issue 75 (2018)
- Year:
- 2018
- Volume:
- 54
- Issue:
- 75
- Issue Sort Value:
- 2018-0054-0075-0000
- Page Start:
- 10622
- Page End:
- 10625
- Publication Date:
- 2018-09-04
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c8cc06397d ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 7695.xml