Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R. (October 2018)

• Record Type: Journal Article
• Authors: Ho, Yih; SH Yang, Yu-Chen; Chin, Yu-Tang; Chou, Szu-Yi; Chen, Yi-Ru; Shih, Ya-Jung; Whang-Peng, Jacqueline; Changou, Chun A.; Liu, Hsuan-Liang; Lin, Shwu-Jiuan; Tang, Heng-Yuan; Lin, Hung-Yun; Davis, Paul J.
• Is Part Of: Food and chemical toxicology. Volume 120(2018)
• Page Start: 346
• Page End: 355
• Publication Date: 2018-10
• Subjects: Leiomyoma -- Stilbenes -- Integrin αvβ3 -- Anti-Proliferation; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2018.07.030
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Leiomyomas (myomas) are the most common benign smooth muscle cell tumor of the myometrium. Resveratrol, a stilbene, has been used as an anti-inflammatory and antitumor agent. In the current study, we investigated the inhibitory effect of resveratrol on the proliferation of primary human myoma cell cultures. Resveratrol arrested cell proliferation via integrin αvβ3. It also inhibited integrin αvβ3 expression and protein accumulation. Concurrently, constitutive AKT phosphorylation in myoma cells was inhibited by resveratrol. Expressions of proapoptotic genes, such as cyclooxygenase (COX)-2, p21 and CDKN2, were induced by resveratrol in myoma cells. On the other hand, expressions of proliferative (anti-apoptotic) genes were either inhibited, as in BCL2, or unchanged, as in cyclin D1 and proliferating cell nuclear antigen (PCNA). The accumulation of insulin-like growth factor (IGF)-1 receptor (IGF-1R) was inhibited by resveratrol in primary myoma cells. IGF-1-induced cell proliferation was inhibited by co-incubation with resveratrol. Therefore, growth modulation of myoma cells occurs via mechanisms dependent on cross-talk between integrin αvβ3 and IGF-1R. Our findings suggest that resveratrol can be considered an alternative therapeutic agent for myomas.