Differences in the associations of anthropometric measures with insulin resistance and type 2 diabetes mellitus between Korean and US populations: Comparisons of representative nationwide sample data. Issue 6 (November 2016)

• Record Type: Journal Article
• Authors: Yoon, Yeong Sook; Choi, Han Seok; Kim, Jin Kuk; Kim, Yu Il; Oh, Sang Woo
• Is Part Of: Obesity research & clinical practice. Volume 10:Issue 6(2016:Nov./Dec.)
• Page Start: 642
• Page End: 651
• Publication Date: 2016-11
• Subjects: AUC-ROC area under the curve in a receiver operating characteristic curve -- BMI body mass index -- HOMA-IR homeostasis model assessment of insulin resistance -- HOMA-β homeostasis model assessment of β cell function -- IR insulin resistance -- NHANES National Health and Nutrition Examination Survey -- WC waist circumference; Ethnic differences -- Body mass index -- Waist circumference -- Insulin resistance -- Type 2 diabetes; Obesity -- Research -- Periodicals; Obesity -- Treatment -- Periodicals; Obesity -- Periodicals; Obésité -- Recherche -- Périodiques; Obésité -- Traitement -- Périodiques; Obesity -- Research; Obesity -- Treatment; Electronic journals; Periodicals; 616.398
• DOI: 10.1016/j.orcp.2015.11.001
• Languages: English
• ISSNs: 1871-403X

Abstract

Highlights: Ethnic differences in association between obesity and IR, diabetes were suggested. US and Korea National Health and Nutrition Examination Survey data were compared. The impact of increasing BMI and WC on HOMA-IR was pronounced in Whites. The impact of increasing BMI and HOMA-IR on FBS was highest in Koreans. Summary: Backgrounds: Variation among ethnic groups in the association between obesity and insulin resistance (IR)/diabetes has been suggested, but studies reported inconsistent results. We evaluated ethnic differences in the association between obesity and insulin resistance (IR)/diabetes. Methods: We conducted a cross-sectional analysis using Korea ( n = 18, 845) and the USA ( n = 4657) National Health and Nutrition Examination Survey(NHANES) 2007–2010. We performed statistical comparisons of AUC-ROC (area under the curve in a receiver operating characteristic curve) values for body mass index (BMI), waist circumference (WC) and homeostasis model assessment of insulin resistance (HOMA-IR) to predict IR or diabetes among different ethnic groups. Results: AUC-ROC values for BMI and WC for predicting IR were highest in Whites (0.8324 and 0.8468) and lowest in Koreans (0.7422 and 0.7367). Whites showed the highest AUC-ROC values for BMI (0.6869) and WC (0.7421) for predicting diabetes, while the AUC-ROC for HOMA-IR was highest in Koreans (0.8861). Linear regression showed significant interactions between ethnicity and the main effects (all P < 0.0001). Increases in BMI were associated with a larger increase in HOMA-IR in Whites ( β = 0.0719) and WC in Hispanics ( β = 0.0324), while BMI was associated with a larger increase in fasting glucose in Koreans ( β = 0.8279) and WC in Blacks ( β = 0.4037). In addition, the slope for fasting glucose with increasing HOMA-IR was steeper in Koreans ( β = 16.5952, P < 0.001) than in other groups. Conclusion: The ability of BMI and WC to predict IR and diabetes was highest in Whites, while the ability of HOMA-IR to predict diabetes was highest in Koreans.