Incidence of childhood cancer in Costa Rica, 2000–2014: An international perspective. (October 2018)

• Record Type: Journal Article
• Authors: Erdmann, Friederike; Li, Tengfei; Luta, George; Giddings, Brenda M.; Torres Alvarado, Guillermo; Steliarova-Foucher, Eva; Schüz, Joachim; Mora, Ana M.
• Is Part Of: Cancer epidemiology. Volume 56(2018:Oct.)
• Page Start: 21
• Page End: 30
• Publication Date: 2018-10
• Subjects: Childhood cancer -- Childhood leukemia -- Incidence -- Incidence trends -- Costa Rica -- Geographical differences; Cancer -- Epidemiology -- Periodicals; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Carcinogenesis -- Periodicals; 616.994005
• DOI: 10.1016/j.canep.2018.07.004
• Languages: English
• ISSNs: 1877-7821

Abstract

Highlights: Incidence patterns were closer to those observed in HICs than found in many LMICs. The observed incidence of lymphoid leukemia ranked among the highest in the world. Lower incidence rates were found for most solid tumors. There was almost no change in incidence rates over time. Some noteworthy geographical variations were observed within Costa Rica. Abstract: Background: Estimating childhood cancer incidence globally is hampered by a lack of reliable data from low- and middle-income countries. Costa Rica is one of the few middle-income countries (MIC) with a long-term high quality nationwide population-based cancer registry. Methods: Data on incident cancers in children aged under 15 years reported to the Costa Rica National Cancer Registry between 2000 and 2014 were analyzed by diagnostic group, age, sex, and geographical region and compared with incidence data for Hispanic and Non-Hispanic White (NHW) children in California, USA. Results: During the 15-year period, 2396 cases of childhood cancer were reported in Costa Rica, resulting in an overall age-standardized incidence rate (ASR) of 140/million. Most frequent cancer types were leukemias (40.5%), malignant central nervous system (CNS) tumors (13.9%), and lymphomas (12.7%). The observed ASR of lymphoid leukemia (46.9/million) ranked high globally. Low rates were found for most solid tumors including malignant CNS tumors, sympathetic nervous system tumors, and soft tissue sarcomas. There was almost no change in incidence rates over time, while geographical variations were observed within Costa Rica. The overall cancer rate in Costa Rica was lower compared to NHW (176.1/million) and Hispanic (161.7/million) children in California. Conclusion: Based on the longstanding registration system, the childhood cancer incidence rates were similar to those observed in other Latin American countries. While a degree of under-ascertainment of cases cannot be excluded, the markedly high leukemia rates, in particular of the lymphoid sub-type deserves further study in this population.