De novo undifferentiated pleomorphic sarcoma arising from a renal allograft: A case report. (2015)

• Record Type: Journal Article
• Authors: Mayor, Grégoire; Wirth, Gregory J.; Sanchez-Pareja, Andrea; La Harpe, Romano; Gehrig, Christian; Iselin, Christophe E.
• Is Part Of: Cancer treatment communications. Volume 3(2015)
• Page Start: 17
• Page End: 20
• Publication Date: 2015
• Subjects: 18-FDG PET 18-fluodeoxyglucose positron emission tomography -- 99-Tc-HDP Technetium 99 m-hydroxymethylene diphosphonate -- CT computed tomography -- FNLCC Fédération Nationale des Centres de Lutte Contre le Cancer -- LOH loss of heterozygosity -- MRI magnetic resonance imaging -- R0 resection complete resection with no microscopic residual tumor (margins are microscopically negative according to the pathologist) -- RCC renal clear cell carcinoma -- RTR renal transplant recipient -- STR short tandem repeat; Renal graft cancer -- Pleomorphic sarcoma -- Kidney transplantation -- Post-transplant malignancy; Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; 616.994005
• DOI: 10.1016/j.ctrc.2015.01.002
• Languages: English
• ISSNs: 2213-0896

Abstract

Abstract: To the best of our knowledge, this is the first report of an undifferentiated pleomorphic sarcoma arising from a renal graft. Transplantectomy was performed in a 47-year old woman presenting to the emergency room because of general weakness. Preoperative workup revealed a 5.5 cm malignant mass of the graft which was not present on routine ultrasound performed 12 months earlier. Following transplantectomy, local recurrence developed despite complete tumor resection and interruption of immunosuppression. Despite radiation therapy, the outcome was ultimately fatal. Genetic analysis revealed that the tumor had arisen from donor tissue. Annual ultrasound surveillance might not be enough effective to screen for these rare high grade neoplasms.