High dietary phosphorus intake is associated with an increased risk of type 2 diabetes in the large prospective E3N cohort study. Issue 5 (October 2018)

• Record Type: Journal Article
• Authors: Mancini, Francesca Romana; Affret, Aurélie; Dow, Courtney; Balkau, Beverley; Clavel-Chapelon, Françoise; Bonnet, Fabrice; Boutron-Ruault, Marie-Christine; Fagherazzi, Guy
• Is Part Of: Clinical nutrition. Volume 37:Issue 5(2018)
• Page Start: 1625
• Page End: 1630
• Publication Date: 2018-10
• Subjects: Type 2 diabetes -- Phosphorus -- Dietary intake -- Risk -- E3N cohort; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2017.07.025
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Phosphorus is an essential nutrient; the adult recommended daily intake ranges from 550 to 700 mg/day, with a tolerated upper limit of 4000 mg/day. Phosphorus intake has increased in the general population in recent years, and simultaneously an alarming rise of type 2 diabetes incidences has been observed. No study has investigated the relationship between phosphorus intake and the risk of type 2 diabetes. To evaluate the association between phosphorus intake and incidence of type 2 diabetes. Among 71, 270 women from the French E3N-EPIC cohort, 1845 cases of incident type 2 diabetes were validated during follow-up (1993–2011). Adjusted Cox proportional hazards regression models were used to calculate hazard ratios and 95% confidence intervals (95% CI) for the associations between phosphorus intake and type 2 diabetes risk, adjusted on potential confounders. The overall mean (±SD) phosphorus intake was 1477 mg/day (±391 mg/day). High phosphorus intake was associated with risk of type 2 diabetes. In multivariate models, compared with women in the 1st quartile of phosphorus intake (<1203 mg/day), those included in the 2nd (1203–1434.0 mg/day), 3rd (1434–1700 mg/day), and 4th (>1700 mg/day) were at a higher risk of type 2 diabetes, with a hazards ratios (95% CI) of 1.18 (1.00–1.38), 1.41 (1.20–1.66) and 1.54 (1.25–1.90), respectively. Our results may have important public health implications for dietary recommendations in the prevention of type 2 diabetes. More studies are warranted to better understand the biological mechanisms underlying this positive association.