Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits. Issue 5 (October 2018)

• Record Type: Journal Article
• Authors: Dumont, Julie; Goumidi, Louisa; Grenier-Boley, Benjamin; Cottel, Dominique; Marécaux, Nadine; Montaye, Michèle; Wagner, Aline; Arveiler, Dominique; Simon, Chantal; Ferrières, Jean; Ruidavets, Jean-Bernard; Amouyel, Philippe; Dallongeville, Jean; Meirhaeghe, Aline
• Is Part Of: Clinical nutrition. Volume 37:Issue 5(2018)
• Page Start: 1683
• Page End: 1689
• Publication Date: 2018-10
• Subjects: FADS1 gene -- Fatty acid -- Diet -- Linoleic acid -- Obesity -- Lipid; AA arachidonic acid -- ALA α-linolenic acid -- BMI body mass index -- DGLA dihomo-γ-linolenic acid -- FADS1 fatty acid desaturase 1 -- GWAS genome-wide association study -- HDL high-density lipoprotein -- LA linoleic acid -- LC-PUFA long-chain polyunsaturated fatty acid -- LD linkage disequilibrium -- LDL low-density lipoprotein -- MET metabolic equivalent of task -- PUFA polyunsaturated fatty acid; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2017.07.012
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Blood levels of polyunsaturated fatty acids (PUFAs) are under control of endogenous synthesis via Δ5- and Δ6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet. Genome-wide associations studies (GWAS) reported associations between polymorphisms in FADS1–FADS2 and variations in plasma concentrations of PUFAs, HDL- and LDL-cholesterol and triglycerides. However, it is not established whether dietary PUFAs intake modulates these associations. We assessed whether dietary linoleic acid (LA) or α-linolenic acid (ALA) modulate the association between the FADS1 rs174547 polymorphism (a GWAS hit) and lipid and anthropometric phenotypes. Methods: Dietary intakes of LA and ALA, FADS1 rs174547 genotypes, lipid and anthropometric variables were determined in three French population-based samples (n = 3069). These samples were stratified according to the median dietary LA (<9.5 and ≥9.5 g/d) and ALA (<0.80 and ≥0.80 g/d) intakes. The meta-analysis was performed using a random-effect. Results: Our meta-analysis confirmed the association between rs174547 and plasma lipid levels and revealed an association with waist circumference and body mass index. These associations were not modified by dietary ALA intake (all p-interaction > 0.05). In contrast, the associations with HDL-cholesterol levels, waist circumference and BMI were modulated by the dietary intake of LA (p interaction < 0.05). In high LA consumers only, the rs174547 minor allele was significantly associated with lower HDL-cholesterol levels (β = −0.05 mmol/L, p = 0.0002). Furthermore, each copy of the rs174547 minor allele was associated with a 1.58 cm lower waist circumference (p = 0.0005) and a 0.46 kg m −2 lower BMI (p = 0.01) in the low LA intake group, but not in the high LA intake group. Conclusions: The present study suggests that dietary LA intake may modulate the association between the FADS gene variants and HDL-cholesterol concentration, waist circumference and BMI. These gene–nutrient interactions, if confirmed, suggest that subjects carrying the rs174547 minor allele might benefit from low dietary LA intakes.