Study on effects of steroid on clinical course, short-term and long-term outcomes in neonates with meconium aspiration syndrome. Issue 5 (October 2018)

• Record Type: Journal Article
• Authors: Rana, Kriti Sundar; Konar, Mithun Chandra; Islam, Kamirul; Barik, Kanai Lal; Nayek, Kaustav; Datta, Asok Kumar
• Is Part Of: Journal of neonatal nursing. Volume 24:Issue 5(2018)
• Page Start: 257
• Page End: 260
• Publication Date: 2018-10
• Subjects: Meconium aspiration syndrome -- Steroids -- Neonates -- Short-term outcome -- Long-term outcome; Newborn infants -- Care -- Periodicals; Newborn infants -- Diseases -- Periodicals; Neonatal intensive care -- Periodicals; Soins infirmiers en néonatologie -- Périodiques; Infant, Newborn, Diseases -- Periodicals; Intensive Care, Neonatal -- Periodicals; Neonatal Nursing -- Periodicals; 618.9200231
• DOI: 10.1016/j.jnn.2018.06.001
• Languages: English
• ISSNs: 1355-1841

Abstract

Abstract: The definite role of steroids in meconium aspiration syndrome (MAS), their safety and short-term as well as long-term outcomes are yet to be evaluated in large clinical trials; although some recent studies have yielded encouraging results. A randomized controlled trial was conducted over three years involving 275 neonates, where one group (n = 137) received intravenous (IV) methylprednisolone and nebulized budesonide along with the conventional management (IV normal saline and nebulized 3% saline), and the other group (n = 138) received conventional management only. These infants were followed up at 1, 3, and 6 months after discharge. We noticed a remarkable and statistically significant improvement in the clinical course including reduction in the Downes' score, oxygen dependency, the need of mechanical ventilation, and respiratory distress as well as a reduction in long-term complications including bronchopulmonary dysplasia, cerebral palsy etc.; in neonates receiving IV and nebulized steroid. We also did not observe any increased rate of sepsis, hypoglycemia, necrotizing enterocolitis in this group.