Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi. Issue 20 (15th October 2016)

• Record Type: Journal Article
• Authors: Liu, Ya-Ping; Yue, Grace Gar-Lee; Lee, Julia Kin-Ming; Feng, Tao; Zhao, Yun-Li; Li, Yan; Lau, Clara Bik-San; Luo, Xiao-Dong
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 20(2016)
• Page Start: 4895
• Page End: 4898
• Publication Date: 2016-10-15
• Subjects: JZWMWARIKBVAEK-FTBHSVGHSA-N; Melodinine V -- Bisindole -- Inhibited cell proliferation -- Cell cycle arrest -- Cellular apoptosis -- HT-29 cells; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.09.023
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: Melodinine V (1 ) was an antitumor bisindole alkaloid possessed a vincanol–eburenine skeleton. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29. Melodinine V inhibited cell proliferation in a concentration-dependent manner. Melodinine V induced cell cycle arrest at G1 phase and cellular apoptosis. Abstract: Melodinine V (1 ) with a vincanol–eburenine skeleton, was isolated from Melodinus henryi . The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29 and inhibited cell proliferation in a concentration-dependent manner. It induced cell cycle arrest at G1 phase and cellular apoptosis by increasing histone-associated DNA fragmentation in the treated HT-29 cells.