Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris. Issue 20 (15th October 2016)

• Record Type: Journal Article
• Authors: Whuang, Ta-Yuan; Tsai, Wen-Cheng; Chen, Nan-Fu; Chen, Zhi-Cheng; Tsui, Kuan-Hao; Wen, Zhi-Hong; Su, Yin-Di; Chang, Yu-Chia; Chen, Yu-Hsin; Lu, Mei-Chin; Fang, Lee-Shing; Chen, Jih-Jung; Wu, Tung-Ying; Wu, Yang-Chang; Sung, Ping-Jyun
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 20(2016)
• Page Start: 4966
• Page End: 4969
• Publication Date: 2016-10-15
• Subjects: Nephthea columnaris -- 19-Norsterol -- Columnaristerol -- Cytotoxicity; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.09.007
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Columnaristerol A (1 ), a rare natural 19-norsterol possessing a 10β-hydroxy group was isolated from the Formosan octocoral Nephthea columnaris, and its structure was elucidated by spectroscopic methods. Sterol1 was found to be a cytotoxic agent that exhibited in vitro moderate cytotoxic activity against MOLT-4 and SUP-T1 human leukemia–lymphoma cell lines.