Links of genome replication, transcriptional silencing and chromatin dynamics. (December 2016)

• Record Type: Journal Article
• Authors: Gutierrez, Crisanto; Desvoyes, Bénédicte; Vergara, Zaida; Otero, Sofía; Sequeira-Mendes, Joana
• Is Part Of: Current opinion in plant biology. Volume 34(2016)
• Page Start: 92
• Page End: 99
• Publication Date: 2016-12
• Subjects: Plant molecular biology -- Periodicals; 571.205
• DOI: 10.1016/j.pbi.2016.10.005
• Languages: English
• ISSNs: 1369-5266

Abstract

Highlights: The chromatin landscape is crucial for pre-RC assembly and ORI specification. Components of the DNA replication machinery participate in transcriptional silencing. Transcriptional defects after H3K27me1 loss lead to genomic instability. The H3.1/H3.3 ratio defines cell proliferation status during organogenesis. Abstract : Genome replication in multicellular organisms involves duplication of both the genetic material and the epigenetic information stored in DNA and histones. In some cases, the DNA replication process provides a window of opportunity for resetting chromatin marks in the genome of the future daughter cells instead of transferring them identical copies. This crucial step of genome replication depends on the correct function of DNA replication factors and the coordination between replication and transcription in proliferating cells. In fact, the histone composition and modification status appears to be intimately associated with the proliferation potential of cells within developing organs. Here we discuss these topics in the light of recent advances in our understanding of how genome replication, transcriptional silencing and chromatin dynamics are coordinated in proliferating cells.