Berberine and inflammatory bowel disease: A concise review. (November 2016)

• Record Type: Journal Article
• Authors: Habtemariam, Solomon
• Is Part Of: Pharmacological research. Volume 113(2016:Nov.)Part A
• Page Start: 592
• Page End: 599
• Publication Date: 2016-11
• Subjects: Berberine -- Inflammatory bowel disease -- Anti-inflammatory mechanisms -- Antinociceptive -- Epithelial barrier protection -- Anti-diarrhoeal; AP1 activator protein 1 -- ATF activating transcription factor -- COX-2 cyclooxygenase-2 -- ERK1/2 extracellular signal-regulated protein kinases 1 and 2 -- H2O2 hydrogren peroxide -- HO-1 heme oxygenase -- iNOS inducible nitric oxide synthase -- IBD inflammatory bowel disease -- ICAM-1 intercellular adhesion milecue-1 -- IFN-γ interferon gamma -- IL interleukin -- IBS irritable bowel syndrome -- JAK Janus kinase -- JNK c-Jun N-terminal kinase -- LPS lipopolysaccharide -- δ-DOR δ-opioidreceptors -- μ-MOR μ-opioidreceptors -- MAPK mitogen-activated protein kinases -- NF-κB nuclear factor-κB -- NSAID non-steroidal anti-inflammatory drugs -- Nrf2 (erythroid-derived-2)-related factor-2 -- PI3K/Akt phosphatidylinositide 3-kinases/Protein Kinase B -- PPARγ proliferator-activated receptor-γ -- ROR-γ tRAR-related orphan receptor-γ -- ROS/RNS reactive oxygen/nitrogenous species -- STAT signal transducer and activator of transcription -- TAK1 TGF-activated kinase 1 -- Th T helper cells -- TGF-β transforming growth factor-β -- Treg regulatory T cells -- TNF-α tumour necrosis factor-α; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2016.09.041
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Berberine is the principal component of many popular medicinal plants ( e . g . the genus Berberis, Coptis and Hydrastis among others) with a history of thousands of years of usage in traditional medicine. The numerous pharmacological activities of berberine reported in the last two decades have been attracting high level interests both within the scientific community, clinicians and the public at large. Despite enormous amount of efforts have been placed to show its therapeutic value for inflammatory bowel diseases (IBD), however, comprehensive up-to-date review article in this field is not yet available. In this communication, literature data from in vitro and in vivo experiments were scrutinised and concisely presented to demonstrate its anti-IBD potential. Beyond the known general antioxidant and anti-inflammatory effects of berberine, IBD-specific effects including gut epithelial barrier pathology, T cells as emerging targets, antinociceptive and other effects are discussed.