Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: A cross-sectional study. Issue 6 (June 2016)

• Record Type: Journal Article
• Authors: Riis, Robert G.C.; Gudbergsen, Henrik; Henriksen, Marius; Ballegaard, Christine; Bandak, Elisabeth; Röttger, Diana; Bliddal, Henning; Hansen, Bjarke Brandt; Hangaard, Stine; Boesen, Mikael
• Is Part Of: European journal of radiology. Volume 85:Issue 6(2016)
• Page Start: 1099
• Page End: 1108
• Publication Date: 2016-06
• Subjects: BLOKS Boston-Leeds Osteoarthritis Knee Score -- DCE-MRI dynamic contrast-enhanced MRI -- EES extravascular, extracellular space -- IRE initial rate of enhancement -- KOA knee osteoarthritis -- KOOS knee injury and osteoarthritis outcome score -- Ktrans volume transfer coefficient between plasma and EES -- ME maximum enhancement -- MOAKS MRI Osteoarthritis Knee Score -- Nvoxel the number of voxels with plateau or washout patterns (i.e. the highest perfused voxels) -- PROM patient reported outcome measures -- ROI region of interest -- TIC time-intensity-curve -- Ve proportion of EES within a ROI/VOI -- VOI volume of interest (consisting of ≥ 2 ROIs); Dynamic contrast-enhanced magnetic resonance imaging -- Magnetic resonance imaging -- Knee osteoarthritis -- Synovitis -- Pain; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2016.03.017
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract: Objectives: To investigate the association between pain and peripatellar-synovitis on static and dynamic contrast-enhanced MRI in knee osteoarthritis. Methods: In a cross-sectional setting, knee synovitis was assessed using 3-Tesla MRI and correlated with pain using the knee injury and osteoarthritis outcome score (KOOS). Synovitis was assessed in the peripatellar recesses with: (i) dynamic contrast-enhanced (DCE)-MRI, using both pharmacokinetic and heuristic models, (ii) contrast-enhanced (CE)-MRI, and (iii) non-CE-MRI. The DCE-MRI variable IRExNvoxel was chosen as the primary variable in the analyses. Results: Valid data were available in 94 persons with a mean age of 65 years, a BMI of 32.3 kg/m 2 and a mean Kellgren-Lawrence grade of 2.5. IRExNvoxel showed a statically significant correlation with KOOS-Pain (r = −0.34; p = 0.001), as was the case with all DCE-variables but one. Correlations between static MRI-variables and KOOS-Pain ranged between −0.21 < r < −0.29 (p < 0.040). Intraclass correlation coefficients ranged between 0.90-0.99 for the heuristic and 0.66-0.93 for the pharmacokinetic DCE-MRI variables. Conclusions: The results confirm an association between peripatellar-synovitis and pain in KOA. Overall, DCE-MRI showed stronger correlations with KOOS-Pain compared to static MRI. DCE-MRI analyses were highly reproducible and have the potential to be used to further investigate the role of inflammation and perfusion in KOA.