Real-time Image-guided Adaptive-predictive Prostate Radiotherapy using Rectal Diameter as a Predictor of Motion. Issue 3 (March 2017)

• Record Type: Journal Article
• Authors: Oates, R.; Brown, A.; Tan, A.; Foroudi, F.; Lim Joon, M.; Schneider, M.; Herschtal, A.; Kron, T.
• Is Part Of: Clinical oncology. Volume 29:Issue 3(2017)
• Page Start: 180
• Page End: 187
• Publication Date: 2017-03
• Subjects: Adaptive -- IGRT -- NTCP -- prostate cancer -- radiotherapy; Oncology -- Periodicals; Tumors -- Periodicals; Cancer -- Treatment -- Periodicals; Radiotherapy -- Periodicals; Neoplasms -- Periodicals; Cancer -- Radiotherapy; Cancer -- Treatment; Oncology; Medical radiology; Radiotherapy; Tumors; Electronic journals; Periodicals; 616.994
• DOI: 10.1016/j.clon.2016.09.019
• Languages: English
• ISSNs: 0936-6555

Abstract

Abstract: Aims: To investigate a relationship between maximum rectal diameter (MRD) on pre-treatment cone beam computed tomography (CBCT) and intra-fraction prostate motion, in the context of an adaptive image-guided radiotherapy (IGRT) method. Materials and methods: The MRD was measured on 2125 CBCTs from 55 retrospective patient datasets and related to prostate displacement from intra-fraction imaging. A linear regression model was developed to determine a threshold MRD associated with a high probability of small prostate displacement. Standard and reduced adaptive margin plans were created to compare rectum and bladder normal tissue complication probability (NTCP) with each method. Results: A per-protocol analysis carried out on 1910 fractions from 51 patients showed with 90% confidence that for a MRD ≤ 3 cm, prostate displacement will be ≤5 mm and that for a MRD ≤ 3.5 cm, prostate displacement will be ≤5.5 mm. In the first scenario, if adaptive therapy was used instead of standard therapy, median reductions in NTCP for rectum and bladder were 0.5% (from 9.5% to 9%) and 1.3% (from 6.6% to 5.3%), respectively. In the second scenario, the NTCP for rectum and bladder would have median reductions of 1.1% and 2.6%, respectively. Conclusions: We have identified a potential method for adaptive prostate IGRT based upon predicting small prostate intra-fraction motion by measuring MRD on pre-treatment CBCT. Highlights: A method for image-guided adaptive prostate radiotherapy is proposed. Existing and widely available technologies are used. Possible normal tissue complication probability reductions for bladder and rectum.