Structure–activity relationship of indoloquinoline analogs anti-MRSA. Issue 23 (1st December 2015)

• Record Type: Journal Article
• Authors: Zhao, Min; Kamada, Tomonori; Takeuchi, Aya; Nishioka, Hiromi; Kuroda, Teruo; Takeuchi, Yasuo
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 23(2015)
• Page Start: 5551
• Page End: 5554
• Publication Date: 2015-12-01
• Subjects: Indoloquinoline -- Benzofuroquinoline -- Indenoquinoline -- Anti-MRSA -- Structure–activity; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.10.058
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Indolo[3, 2- b ]quinoline analogs (3a –3s ), 4-(acridin-9-ylamino) phenol hydrochloride (4 ), benzofuro[3, 2- b ]quinoline (3t ), indeno[1, 2- b ]quinolines (3u and3v ) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure–activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.